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Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results
Adipose (fat) tissue is metabolically active and plays a role in hormone production and metabolism
Estos medicamentos solo se consideran como tratamiento de segunda lnea, despus de haber aplicado medidas bsicas como una alimentacin equilibrada y actividad fsica regular sin resultados suficientes
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